Annexin



Annexins are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. They consist of 2 domains - the C-terminal core and the N-terminal head. Annexins divide into species and are numbered from I to XII. Annexin V is the most abundant scaffolding protein. In the annexin image calcium ions are shown as green balls.

Annexin I
2q4c, 1ycn - AnI - Arabidopsis thaliana

1mcx, 1hm6 - pAnI - pig

1qls - pAnI head+calgizzarrin

1bo9 - hAnI head - human NMR

1ain - hAnI

Annexin II
2hyu, 2hyv - hAnII+heparin oligosaccharide

2hyw, 1xjl - hAnII+Ca

1w7b - hAnII

1bt6 - hAnII head+calpactin light chain

Annexin III
1aii, 1axn - hAnIII

Annexin IV
2zhi, 2zhj, rAnIV+Na - rat

2zoc - hAnIV

1i4a - cAnIV (mutant) - cow

1aow, 1ann - cAnIV

Annexin V
2ie6, 2ie7, rAnV

1n41, 1n42, 1n44, 2h0k, 2h0l, 2h0m, 1bc0, 1bc1, 1bc3, 1bcw, 1bcy, 1bcz - rAnV (mutant)

1g5n - rAnV+ heparin oligosaccharide

1a8a, 1a8b - rAnV+phospholipid analog

2ran - rAnV+Ca

1yii – chAnV+Ca – chicken

1yj0 - chAnV+Zn

1ala - ChAnV

1hak - hAnV+K-201

1sav - hAnV (thioproline)

1hvd, 1hve, 1hvf, 1hvg - hAnV (mutant)

1anw, 1avh, 1avr - hAnV

1anx - hAnV+Ca

Annexin VI
1m9i - hAnVI (mutant)

1avc - cAnVI+Ca

Annexin VIII
1w3w - hAnVIII

1w45 - hAnVIII (mutant)

Annexin XII
1dm5 - HvAnXII (mutant) - Hydra vulgaris

1aei - HvAnXII

Other annexins
1dk5 - An24 - Capsicom annuum

3brx - coAnGH1+Ca - cotton

1n00 - coAnGH1